Exploiting Cancer's Achilles' Heel to
And Improve Patient Outcomes
Our cells experience millions of DNA damaging events every day.i DNA damage response (DDR) is a collection of processes that identify and correct DNA damage.
Many cancers harbor a defect in natural DDR mechanisms that allow tumor cells to evade the human immune system and grow unchecked into life-threatening malignancies.ii
We are developing precision medicines that selectively target and kill cancer cells using leading-edge science to discover and advance innovative cancer treatments with the potential to improve patient outcomes across multiple tumor types.
i Lodish et al. Molecular Biology of the Cell (2004)
ii Zhang et al. Role of DNA repair defects in predicting immunotherapy response. (2020)